Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human appendix with VWF polyclonal antibody (Cat # PAB30325) shows secreted positivity in blood vessels at 1:200-1:500 dilution.
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq