Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human spleen with APOBEC3G polyclonal antibody (Cat # PAB30317) shows strong cytoplasmic positivity in cells in red pulp at 1:200-1:500 dilution.
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq
DNA dC->dU editing enzyme,OTTHUMP00000028911,phorbolin-like protein MDS019