Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human oral mucosa with CDH3 polyclonal antibody (Cat # PAB30316) shows strong cytoplasmic and membranous positivity in squamous epithelial cells at 1:50-1:200 dilution.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq
cadherin 3, type 1,calcium-dependent adhesion protein, placental