PAPPA polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human PAPPA.
Immunogen
Recombinant protein corresponding to human PAPPA.
Sequence
SCLDHNSESIILPMNVTVRDIPHWLNPTRVERVVCTAGLKWYPHPALIHCVKGCEPFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRDPQAQEHSRKDL
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human placenta with PAPPA polyclonal antibody (Cat # PAB30315) shows strong cytoplasmic positivity in trophoblastic cells at 1:50-1:200 dilution. -
Gene Info — PAPPA
Entrez GeneID
5069Protein Accession#
Q13219Gene Name
PAPPA
Gene Alias
ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
Gene Description
pregnancy-associated plasma protein A, pappalysin 1
Omim ID
176385Gene Ontology
HyperlinkGene Summary
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq
Other Designations
OTTHUMP00000022806|aspecific BCL2 ARE-binding protein 2|differentially placenta 1 expressed protein|insulin-like growth factor-dependent IGF binding protein-4 protease|pregnacy-associated plasma protein A|pregnancy-associated plasma protein A
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Interactome
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Disease
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