PIGA polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human PIGA.
Immunogen
Recombinant protein corresponding to human PIGA.
Sequence
FADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSITIVVVSRLVYRKGIDLLSGIIPELCQKYPDLNFIIGGEGPKRII
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human rectum with PIGA polyclonal antibody (Cat # PAB30310) shows strong cytoplasmic positivity in glandular cells at 1:200-1:500 dilution. -
Gene Info — PIGA
Entrez GeneID
5277Protein Accession#
P37287Gene Name
PIGA
Gene Alias
GPI3, PIG-A
Gene Description
phosphatidylinositol glycan anchor biosynthesis, class A
Omim ID
311770Gene Ontology
HyperlinkGene Summary
This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. [provided by RefSeq
Other Designations
GLCNAC-PI synthesis protein|GPI anchor biosynthesis|OTTHUMP00000022959|phosphatidylinositol N-acetylglucosaminyltransferase subunit A|phosphatidylinositol glycan, class A (paroxysmal nocturnal hemoglobinuria)|phosphatidylinositol-glycan biosynthesis, clas
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Interactome
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Pathway
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