Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human rectum with PIGA polyclonal antibody (Cat # PAB30310) shows strong cytoplasmic positivity in glandular cells at 1:200-1:500 dilution.
This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. [provided by RefSeq
GLCNAC-PI synthesis protein,GPI anchor biosynthesis,OTTHUMP00000022959,phosphatidylinositol N-acetylglucosaminyltransferase subunit A,phosphatidylinositol glycan, class A (paroxysmal nocturnal hemoglobinuria),phosphatidylinositol-glycan biosynthesis, clas