Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with SLAMF6 polyclonal antibody (Cat # PAB30281) shows strong cytoplasmic positivity in cells in tubules with distinct extracellular positivity.
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. [provided by RefSeq
NTBA receptor,OTTHUMP00000024348,activating NK receptor,natural killer-, T- and B-cell antigen