Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with ART1 polyclonal antibody (Cat # PAB30277) shows strong cytoplasmic and membranous positivity in cells in tubules.
ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq