Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with DICER1 polyclonal antibody (Cat # PAB30244) shows strong cytoplasmic positivity in cells within distal tubules and glomeruli at 1:200 - 1:500 dilution.
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Dicer1, Dcr-1 homolog,K12H4.8-LIKE,dicer 1, double-stranded RNA-specific endoribonuclease,dicer1,helicase with RNAse motif,helicase-moi