CRKL polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of human RT-4 cell line with CRKL polyclonal antibody (Cat # PAB30215).
Western Blot (Cell lysate)
Western blot analysis of Lane 1: NIH/3T3 cell lysate, Lane 2: NBT-II cell lysate, and Lane 3: PC-12 cell lysate with CRKL polyclonal antibody (Cat # PAB30215).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human fallopian tube shows membranous and cytoplasmic positivity in glandular cells with CRKL polyclonal antibody (Cat # PAB30215).
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human CRKL.
Immunogen
Recombinant protein corresponding to amino acids 125 - 301 of human CRKL.
Sequence
LEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPDE
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20 - 1:50)
Western Blot (1:100 - 1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of human RT-4 cell line with CRKL polyclonal antibody (Cat # PAB30215).Western Blot (Cell lysate)
Western blot analysis of Lane 1: NIH/3T3 cell lysate, Lane 2: NBT-II cell lysate, and Lane 3: PC-12 cell lysate with CRKL polyclonal antibody (Cat # PAB30215).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human fallopian tube shows membranous and cytoplasmic positivity in glandular cells with CRKL polyclonal antibody (Cat # PAB30215). -
Gene Info — CRKL
Entrez GeneID
1399Protein Accession#
P46109Gene Name
CRKL
Gene Alias
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Gene Description
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Omim ID
602007Gene Ontology
HyperlinkGene Summary
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic
Other Designations
v-crk avian sarcoma virus CT10 oncogene homolog-like
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Interactome
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Pathway
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Disease
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