TYRP1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human TYRP1.
Immunogen
Recombinant protein corresponding to amino acids 257- 377 of human TYRP1.
Sequence
VCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLH
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200 - 1:500)
Western Blot (1:100 - 1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of Lane 1: Negative control (vector only transfected HEK293T lysate), Lane 2: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells) with TYRP1 polyclonal antibody (Cat # PAB30213).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin shows distinct cytoplasmic positivity in melanocytes with TYRP1 polyclonal antibody (Cat # PAB30213). -
Gene Info — TYRP1
Entrez GeneID
7306Protein Accession#
P17643Gene Name
TYRP1
Gene Alias
CAS2, CATB, GP75, TRP, TYRP, b-PROTEIN
Gene Description
tyrosinase-related protein 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq
Other Designations
associated with iris pigmentation
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Interactome
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Pathway
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Disease
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