Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast carcinoma tissue with YWHAZ (phospho S58) polyclonal antibody (Cat # PAB30172) (left) or the same antibody pre-incubated with blocking peptide (right).
Immunofluorescent staining of methanol-fixed HeLa cells showing cytoplasmic and centrosomal staining with YWHAZ (phospho S58) polyclonal antibody (Cat # PAB30172).
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq