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MCM8 polyclonal antibody

  • Catalog # : PAB30162
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of human MCM8.
  • Immunogen:
  • A synthetic peptide corresponding to C-terminus of human MCM8.
  • Sequence:
  • IRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQH
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 94
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-8 ug/mL)
    Western Blot (0.2-1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (2% sucrose, 0.09% sodium azide).
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western Blot analysis of 721 B lymphoblast cell lysate with MCM8 polyclonal antibody (Cat # PAB30162) at 0.2-1 ug/mL working concentration.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human intestine with MCM8 polyclonal antibody (Cat # PAB30162) at 4-8 ug/mL working concentration.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Protein Accession#:
  • NP_115874;Q9UJA3
  • Gene Name:
  • MCM8
  • Gene Alias:
  • C20orf154,MGC119522,MGC119523,MGC12866,MGC4816,REC,dJ967N21.5
  • Gene Description:
  • minichromosome maintenance complex component 8
  • Gene Summary:
  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
  • Other Designations:
  • DNA replication licensing factor MCM8,MCM8 minichromosome maintenance deficient 8,OTTHUMP00000030217,OTTHUMP00000030218,REC homolog
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