Products

Western Blot (Cell lysate)

Western Blot analysis of Jurkat cell lysate with EXOSC6 polyclonal antibody (Cat # PAB30060) at 5 ug/mL working concentration.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human muscle (A) and human liver (B) with EXOSC6 polyclonal antibody (Cat # PAB30060) at 4-8 ug/mL working concentration.

Entrez GeneID

118460

GeneBank Accession#

NM_058219

Protein Accession#

NP_478126;Q5RKV6

Gene Name

EXOSC6

Gene Alias

EAP4, MTR3, Mtr3p, hMtr3p, p11

Gene Description

exosome component 6

Omim ID

606490

Gene Ontology

Hyperlink

Gene Summary

This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq

Other Designations

Mtr3 (mRNA transport regulator 3)-homolog|OTTHUMP00000174902|homolog of yeast mRNA transport regulator 3