DLAT polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of human DLAT.
Immunogen
A synthetic peptide corresponding to N-terminus of human DLAT.
Sequence
WTPSSGATPRNRLLLQLLGSPGRRYYSLPPHQKVPLPSLSPTMQAGTIAR
Host
Rabbit
Theoretical MW (kDa)
69
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-8 ug/mL)
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (2% sucrose, 0.09% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of Jurkat cell lysate with DLAT polyclonal antibody (Cat # PAB30033) at 1 ug/mL working concentration.Western Blot (Cell lysate)
Western Blot analysis of Huh7 cell lysate with DLAT polyclonal antibody (Cat # PAB30033) at 1:200 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with DLAT polyclonal antibody (Cat # PAB30033) at 4-8 ug/mL working concentration. -
Gene Info — DLAT
Entrez GeneID
1737GeneBank Accession#
NM_001931Protein Accession#
NP_001922;P10515Gene Name
DLAT
Gene Alias
DLTA, PDC-E2, PDCE2
Gene Description
dihydrolipoamide S-acetyltransferase
Omim ID
608770Gene Ontology
HyperlinkGene Summary
The DLAT gene encodes dihydrolipoamide acetyltransferase (EC 2.3.1.12), the E2 subunit of the mammalian pyruvate dehydrogenase complex (PDC; EC 1.2.4.1) of the inner mitochondrial membrane. Patients with primary biliary cirrhosis (PBC; MIM 109720) show autoantibodies to DLAT.[supplied by OMIM
Other Designations
70 kDa mitochondrial autoantigen of primary biliary cirrhosis|E2 component of pyruvate dehydrogenase complex|M2 antigen complex 70 kDa subunit
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Interactome
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Pathway
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Glycolysis / Gluconeogenesis
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