Products

Western Blot (Cell lysate)

Western Blot analysis of Daudi cell lysate with DAZ2 polyclonal antibody (Cat # PAB30017) at 0.2-1 ug/mL working concentration.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with DAZ2 polyclonal antibody (Cat # PAB30017) at 4-8 ug/mL working concentration.

Entrez GeneID

57055

GeneBank Accession#

NM_001005785

Protein Accession#

NP_001005785;Q13117

Gene Name

DAZ2

Gene Alias

MGC126442, pDP1678

Gene Description

deleted in azoospermia 2

Omim ID

400026

Gene Ontology

Hyperlink

Gene Summary

This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq

Other Designations

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