ALDH4A1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of human ALDH4A1.
Immunogen
A synthetic peptide corresponding to C-terminus of human ALDH4A1.
Sequence
RNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVI
Host
Rabbit
Theoretical MW (kDa)
62
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-8 ug/mL)
Western Blot (1.25 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (2% sucrose, 0.09% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of human fetal liver tissue lysate with ALDH4A1 polyclonal antibody (Cat # PAB29958) at 1.25 ug/mL working concentration.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human muscle with ALDH4A1 polyclonal antibody (Cat # PAB29958) at 4-8 ug/mL working concentration. -
Gene Info — ALDH4A1
Entrez GeneID
8659GeneBank Accession#
NM_003748Protein Accession#
NP_003739;P30038Gene Name
ALDH4A1
Gene Alias
ALDH4, P5CD, P5CDh, P5CDhL, P5CDhS
Gene Description
aldehyde dehydrogenase 4 family, member A1
Gene Ontology
HyperlinkGene Summary
This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000002544|OTTHUMP00000002545|P5C dehydrogenase|aldehyde dehydrogenase 4A1|mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase
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Interactome
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Pathway
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Disease
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