KREMEN1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KREMEN1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human KREMEN1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of KREMEN1 polyclonal antibody (Cat # PAB2991) in A-375 cell line lysates (35 ug/lane).KREMEN1 (arrow) was detected using the purified polyclonal antibody.Flow Cytometry
Flow cytometric analysis of A-375 cells using KREMEN1 polyclonal antibody (Cat # PAB2991)(bottom histogram) compared to a negative control cell (top histogram).
FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. -
Gene Info — KREMEN1
Entrez GeneID
83999Protein Accession#
NP_001034659;Q96MU8Gene Name
KREMEN1
Gene Alias
FLJ31863, KREMEM1, KREMEN, KRM1
Gene Description
kringle containing transmembrane protein 1
Omim ID
609898Gene Ontology
HyperlinkGene Summary
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000028977|kringle-coding gene marking the eye and the nose|kringle-containing transmembrane protein 1
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Interactome
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Disease
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Publication Reference
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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
Mao B, Wu W, Davidson G, Marhold J, Li M, Mechler BM, Delius H, Hoppe D, Stannek P, Walter C, Glinka A, Niehrs C.
Nature 2002 Jun; 417(6889):664.
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Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein.
Nakamura T, Aoki S, Kitajima K, Takahashi T, Matsumoto K, Nakamura T.
Biochimica et Biophysica Acta 2001 Mar; 1518(1-2):63.
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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
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