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SF3A1 polyclonal antibody

  • Catalog # : PAB29879
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against partial synthetic protein of human SF3A1.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 121-170 of human SF3A1.
  • Sequence:
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 89
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunofluorescence (1:250)
    Immunohistochemistry (1:250)
    Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (2% sucrose, 0.09% sodium azide).
  • Storage Instruction:
  • Store at 4°C for up to 1 week. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of 721_B cell lysate with SF3A1 polyclonal antibody (Cat # PAB29879).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human heart with SF3A1 polyclonal antibody (Cat # PAB29879).
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of HeLa cell with SF3A1 polyclonal antibody (Cat # PAB29879) under 4 ug/mL working concentration.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Gene Name:
  • SF3A1
  • Gene Alias:
  • PRP21,PRPF21,SAP114,SF3A120
  • Gene Description:
  • splicing factor 3a, subunit 1, 120kDa
  • Gene Summary:
  • This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • pre-mRNA processing 21,pre-mRNA splicing factor SF3a (120 kDa subunit),spliceosome associated protein 114
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