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NUP98 polyclonal antibody

  • Catalog # : PAB29875
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against partial synthetic protein of human NUP98.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 36-85 of human NUP98.
  • Sequence:
  • AFGTSAFGSSNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTST
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 196
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunofluorescence (1:250)
    Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (2% sucrose, 0.09% sodium azide).
  • Storage Instruction:
  • Store at 4°C for up to 1 week. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western blot analysis of NUP98 transfected HEK 293T cell lysate with NUP98 polyclonal antibody (Cat # PAB29875).
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of HeLa cell with NUP98 polyclonal antibody (Cat # PAB29875).
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4928
  • Gene Name:
  • NUP98
  • Gene Alias:
  • ADIR2,NUP196,NUP96
  • Gene Description:
  • nucleoporin 98kDa
  • Gene Summary:
  • Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq
  • Other Designations:
  • GLFG-repeat containing nucleoporin,Nup98-Nup96,OTTHUMP00000013819,OTTHUMP00000013967,nucleoporin 98kD
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