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Last updated: 2017/12/10
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RASGRF1 polyclonal antibody

  • Catalog # : PAB2980
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of RASGRF1.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to residues surrounding S929 of human RASGRF1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Recommend Usage:
  • Western Blot (1:1000)
    Immunohistochemistry (1:10-50)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of MDA-MB-231 cell lysate (35 ug/lane) with RASGRF1 polyclonal antibody (Cat # PAB2980).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Formalin-fixed and paraffin-embedded human brain tissue reacted with RASGRF1 polyclonal antibody (Cat # PAB2980) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5923
  • Protein Accession#:
  • NP_002882;Q13972
  • Gene Name:
  • RASGRF1
  • Gene Alias:
  • CDC25,CDC25L,GNRP,GRF1,GRF55,H-GRF55,PP13187
  • Gene Description:
  • Ras protein-specific guanine nucleotide-releasing factor 1
  • Gene Summary:
  • The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
  • Other Designations:
  • Ras-specific guanine nucleotide-releasing factor, CDC25 homolog,Ras-specific nucleotide exchange factor CDC25,guanine nucleotide exchange factor,guanine nucleotide-releasing factor, 55 kD
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