RAC1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RAC1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding S71 of human RAC1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of RAC1 polyclonal antibody (Cat # PAB2976). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the RAC1 gene (Lane 2) (Origene Technologies). -
Gene Info — RAC1
Entrez GeneID
5879Protein Accession#
NP_008839;P63000Gene Name
RAC1
Gene Alias
MGC111543, MIG5, TC-25, p21-Rac1
Gene Description
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Omim ID
602048Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
migration-inducing gene 5|migration-inducing protein 5|ras-related C3 botulinum toxin substrate 1|ras-related C3 botulinum toxin substrate 1 isoform Rac1|ras-related C3 botulinum toxin substrate 1 isoform Rac1b|rho family, small GTP binding protein Rac1
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Interactome
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Pathway
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Disease
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Publication Reference
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Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1.
Gorshkova I, He D, Berdyshev E, Usatuyk P, Burns M, Kalari S, Zhao Y, Pendyala S, Garcia JG, Pyne NJ, Brindley DN, Natarajan V.
The Journal of Biological Chemistry 2008 Apr; 283(17):11794.
Application:IF, WB, Human , HPAECs.
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PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1.
Simeone-Penney MC, Severgnini M, Rozo L, Takahashi S, Cochran BH, Simon AR.
American Journal of Physiology. Lung Cellular and Molecular Physiology 2008 Apr; 294(4):L698.
Application:IF, WB-Tr, Human, HASMC cells.
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Non-syndromic mental retardation is not expressed in RAC1 gene polymorphisms.
Wang T, Zhang K, Zheng Z, Gao X, Li R, Zhang F.
Neuroscience Letters 2008 May; 437(2):71.
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Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1.
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