CYP19A1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CYP19A1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CYP19A1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
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Gene Info — CYP19A1
Entrez GeneID
1588Protein Accession#
NP_000094;P11511Gene Name
CYP19A1
Gene Alias
ARO, ARO1, CPV1, CYAR, CYP19, MGC104309, P-450AROM
Gene Description
cytochrome P450, family 19, subfamily A, polypeptide 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000162543|aromatase|cytochrome P450, family 19|cytochrome P450, subfamily XIX (aromatization of androgens)|estrogen synthetase|flavoprotein-linked monooxygenase|microsomal monooxygenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Investigation of hormone receptor expression and its prognostic value in endometrial stromal sarcoma.
Park JY, Baek MH, Park Y, Kim YT, Nam JH.
Virchows Archiv : an International Journal of Pathology 2018 Jul; 473(1):61.
Application:IHC-P, Human, Human endometrial stromal sarcoma.
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Androgen receptor as a prognostic biomarker and therapeutic target in uterine leiomyosarcoma.
Baek MH, Park JY, Park Y, Kim KR, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT, Nam JH.
Journal of Gynecologic Oncology 2018 May; 29(3):e30.
Application:IHC, Human, Tissue microarrays (TMAs).
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Investigation of New Therapeutic Targets in Undifferentiated Endometrial Sarcoma.
Baek MH, Park JY, Rhim CC, Kim JH, Park Y, Kim KR, Nam JH.
Gynecologic and Obstetric Investigation 2017 Jan; 82(4):329.
Application:IHC-P, Human, Human undifferentiated endometrial sarcoma.
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PSA and androgen-related gene (AR, CYP17, and CYP19) polymorphisms and the risk of adenocarcinoma at prostate biopsy.
dos Santos RM, de Jesus CM, Trindade Filho JC, Trindade JC, de Camargo JL, Rainho CA, Rogatto SR.
DNA and Cell Biology 2008 Sep; 27(9):497.
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The synergistic effect of sex hormone-binding globulin and aromatase genes on polycystic ovary syndrome phenotype.
Xita N, Georgiou I, Lazaros L, Psofaki V, Kolios G, Tsatsoulis A.
European Journal of Endocrinology 2008 Jun; 158(6):861.
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Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW.
Pharmacogenetics 2004 Jan; 14(1):1.
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Investigation of hormone receptor expression and its prognostic value in endometrial stromal sarcoma.
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