Western blot analysis of SRC1 (arrow) using rabbit NCOA1 polyclonal antibody (Cat # PAB2970). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NCOA1 gene (Lane 2) (Origene Technologies).
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq