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ALK (phospho Y1604) polyclonal antibody

  • Catalog # : PAB29642
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ALK.
  • Immunogen:
  • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y1604 of human ALK.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 176
  • Reactivity:
  • Human
  • Specificity:
  • ALK (phospho Y1604) polyclonal antibody detects endogenous levels of human ALK only when phosphorylated at tyrosine 1604.
  • Form:
  • Liquid
  • Purification:
  • Affinity chromatography
  • Recommend Usage:
  • Immunohistochemistry (1:50-1:100)
    Immunofluorescence (1:100-1:500)
    Western Blot (1:500-1:3000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of Lane 1: Untreated HepG2 cell lysates, Lane 2: Synthesized peptide treated HepG2 cell lysates reacted with ALK (phospho Y1604) polyclonal antibody (Cat # PAB29642) at 1:500-1:3000 dilution.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of paraffin-embedded human brain tissue reacted with ALK (phospho Y1604) polyclonal antibody (Cat # PAB29642) at 1:50-1:100 dilution. The picture on the right is treated with the synthesized peptide.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of HeLa cells reacted with ALK (phospho Y1604) polyclonal antibody (Cat # PAB29642) at 1:100-1:500 dilution. The picture on the right is treated with the synthesized peptide.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 238
  • Gene Name:
  • ALK
  • Gene Alias:
  • CD246,Ki-1,TFG/ALK
  • Gene Description:
  • anaplastic lymphoma receptor tyrosine kinase
  • Gene Summary:
  • The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq
  • Other Designations:
  • ALK tyrosine kinase receptor,CD246 antigen,anaplastic lymphoma kinase (Ki-1),anaplastic lymphoma kinase Ki-1
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