Immunohistochemical staining of paraffin-embedded human brain tissue reacted with AURKB/AURKC (phospho T236/T202) polyclonal antibody (Cat # PAB29635) at 1:50-1:100 dilution. The picture on the right is treated with the synthesized peptide.
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq
aurora/IPL1-related kinase 3,aurora/IPL1/EG2 protein 2,serine/threonine kinase 13 (aurora/IPL1-like)