AURKB/AURKC (phospho T236/T202) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human AURKB/AURKC.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T236/T202 of human AURKB/AURKC.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
AURKB/AURKC (phospho T236/T202) polyclonal antibody detects endogenous levels of human AURKB/AURKC only when phosphorylated at threonine 236 and threonine 202.
Form
Liquid
Purification
Affinity chromatography
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded human brain tissue reacted with AURKB/AURKC (phospho T236/T202) polyclonal antibody (Cat # PAB29635) at 1:50-1:100 dilution. The picture on the right is treated with the synthesized peptide. -
Gene Info — AURKC
Entrez GeneID
6795Protein Accession#
Q9UQB9Gene Name
AURKC
Gene Alias
AIE2, AIK3, AurC, STK13, aurora-C
Gene Description
aurora kinase C
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
aurora/IPL1-related kinase 3|aurora/IPL1/EG2 protein 2|serine/threonine kinase 13 (aurora/IPL1-like)
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Gene Info — AURKB
Entrez GeneID
9212Protein Accession#
Q9UQB9Gene Name
AURKB
Gene Alias
AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, STK12, STK5
Gene Description
aurora kinase B
Omim ID
604970Gene Ontology
HyperlinkGene Summary
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM
Other Designations
aurora-1|aurora-B|serine/threonine kinase 12
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Interactome
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Disease
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