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KCNJ11 (phospho T224) polyclonal antibody

  • Catalog # : PAB29633
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of human KCNJ11.
  • Immunogen:
  • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T224 of human KCNJ11.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 40
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • KCNJ11 (phospho T224) polyclonal antibody detects endogenous levels of human KCNJ11 only when phosphorylated at threonine 224.
  • Form:
  • Liquid
  • Purification:
  • Affinity chromatography
  • Recommend Usage:
  • Immunofluorescence (1:100-1:500)
    Western Blot (1:500-1:3000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of Lane 1: Untreated HeLa cell lysates, Lane 2: Synthesized peptide treated HeLa cell lysates reacted with KCNJ11 (phospho T224) polyclonal antibody (Cat # PAB29633) at 1:500-1:3000 dilution.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of HUVEC cells reacted with KCNJ11 (phospho T224) polyclonal antibody (Cat # PAB29633) at 1:100-1:500 dilution. The picture on the right is treated with the synthesized peptide.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 3767
  • Gene Name:
  • KCNJ11
  • Gene Alias:
  • BIR,HHF2,IKATP,KIR6.2,MGC133230,PHHI,TNDM3
  • Gene Description:
  • potassium inwardly-rectifying channel, subfamily J, member 11
  • Gene Summary:
  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). [provided by RefSeq
  • Other Designations:
  • ATP-sensitive inward rectifier potassium channel 11,beta-cell inward rectifier subunit,inwardly rectifying potassium channel KIR6.2,potassium inwardly-rectifying channel J11
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