Immunohistochemical staining of human brain tissue by NTRK1 (phospho Y791) polyclonal antibody (Cat# PAB29628) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
OTTHUMP00000038736,Oncogene TRK,high affinity nerve growth factor receptor,tyrosine kinase receptor A