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APP (phospho T743/668) polyclonal antibody

  • Catalog # : PAB29627
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of human APP.
  • Immunogen:
  • A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T743/668 of human APP.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 140
  • Reactivity:
  • Human, Mouse, Rabbit
  • Specificity:
  • APP (phospho T743/668) polyclonal antibody detects endogenous level of APP only when phosphorylated at threonine 743/668.
  • Form:
  • Liquid
  • Purification:
  • Affinity Chromatography
  • Recommend Usage:
  • Immunofluorescence (1:100-1:200)
    Immunohistochemistry (1:50-1:100)
    Western Blot (1:500-1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of Lane 1: antigen-specific peptide treated cos-7 cells, Lane 2: cos-7 cells with APP (phospho T743/668) polyclonal antibody (Cat# PAB29627) at 1:500-1:1000 dilution.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of human brain tissue by APP (phospho T743/668) polyclonal antibody (Cat# PAB29627) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of methanol-fixed Hela cells using APP (phospho T743/668) polyclonal antibody (Cat# PAB29627) at 1:100-1:200 dilution.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 351
  • Gene Name:
  • APP
  • Gene Alias:
  • AAA,ABETA,ABPP,AD1,APPI,CTFgamma,CVAP,PN2
  • Gene Description:
  • amyloid beta (A4) precursor protein
  • Gene Summary:
  • This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • A4 amyloid protein,amyloid beta A4 protein,amyloid-beta protein,beta-amyloid peptide,cerebral vascular amyloid peptide,peptidase nexin-II,protease nexin-II
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