Immunohistochemical staining of human breast cancer tissue by RB1 (phospho S780) polyclonal antibody (Cat# PAB29613) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
Immunofluorescent staining of methanol-fixed Hela cells using RB1 (phospho S780) polyclonal antibody (Cat# PAB29613) at 1:100-1:200 dilution.
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq
OTTHUMP00000018397,retinoblastoma suspectibility protein,retinoblastoma-associated protein