CAV1 (phospho Y14) polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of Lane 1: 3T3 cells, Lane 2: H2O2 treated 3T3 cells with CAV1 (phospho Y14) polyclonal antibody (Cat# PAB29603) at 1:500-1:1000 dilution.
Immunofluorescence
Immunofluorescent staining of methanol-fixed Hela cells using CAV1 (phospho Y14) polyclonal antibody (Cat# PAB29603) at 1:100-1:200 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human CAV1.
Immunogen
A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y14 of human CAV1.
Host
Rabbit
Theoretical MW (kDa)
24
Reactivity
Human, Mouse, Rabbit
Specificity
CAV1 (phospho Y14) polyclonal antibody detects endogenous level of CAV1 only when phosphorylated at tyrosine 14.
Form
Liquid
Purification
Affinity Chromatography
Recommend Usage
Immunofluorescence (1:100-1:200)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: 3T3 cells, Lane 2: H2O2 treated 3T3 cells with CAV1 (phospho Y14) polyclonal antibody (Cat# PAB29603) at 1:500-1:1000 dilution.Immunofluorescence
Immunofluorescent staining of methanol-fixed Hela cells using CAV1 (phospho Y14) polyclonal antibody (Cat# PAB29603) at 1:100-1:200 dilution. -
Gene Info — CAV1
Entrez GeneID
857Protein Accession#
Q03135Gene Name
CAV1
Gene Alias
BSCL3, CAV, CGL3, MSTP085, VIP21
Gene Description
caveolin 1, caveolae protein, 22kDa
Omim ID
601047Gene Ontology
HyperlinkGene Summary
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [provided by RefSeq
Other Designations
OTTHUMP00000025031|caveolae protein, 22-kD|caveolin 1|caveolin 1 caveolae protein, 22kD|caveolin 1, alpha isoform|caveolin 1, beta isoform|caveolin-1 beta isoform protein|cell growth-inhibiting protein 32
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Interactome
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Pathway
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Disease
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