IGF1R (phospho Y1165/Y1166) polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of Lane 1: 293 cells, Lane 2: Insulin treated 293 cells with IGF1R (phospho Y1165/Y1166) polyclonal antibody (Cat# PAB29602) at 1:500-1:1000 dilution.
Immunofluorescence
Immunofluorescent staining of methanol-fixed MCF-7 cells using IGF1R (phospho Y1165/Y1166) polyclonal antibody (Cat# PAB29602) at 1:100-1:200 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human IGF1R.
Immunogen
A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y1165/Y1166 of human IGF1R.
Host
Rabbit
Theoretical MW (kDa)
200, 95
Reactivity
Human, Mouse, Rabbit
Specificity
IGF1R (phospho Y1165/Y1166) polyclonal antibody detects endogenous level of IGF1R only when phosphorylated at tyrosine 1165/tyrosine 1166.
Form
Liquid
Purification
Affinity Chromatography
Recommend Usage
Immunofluorescence (1:100-1:200)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: 293 cells, Lane 2: Insulin treated 293 cells with IGF1R (phospho Y1165/Y1166) polyclonal antibody (Cat# PAB29602) at 1:500-1:1000 dilution.Immunofluorescence
Immunofluorescent staining of methanol-fixed MCF-7 cells using IGF1R (phospho Y1165/Y1166) polyclonal antibody (Cat# PAB29602) at 1:100-1:200 dilution. -
Gene Info — IGF1R
Entrez GeneID
3480Protein Accession#
P08069Gene Name
IGF1R
Gene Alias
CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216
Gene Description
insulin-like growth factor 1 receptor
Omim ID
147370Gene Ontology
HyperlinkGene Summary
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq
Other Designations
soluble IGF1R variant 1|soluble IGF1R variant 2
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Interactome
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Pathway
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Disease
- Abortion
- Adenocarcinoma
- Adenoma
- Alzheimer disease
- Anemia
- Aneuploidy
- Atherosclerosis
- Bacteremia
- Barrett Esophagus
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