Immunohistochemical staining of human breast cancer tissue by IGF1R (phospho Y1161) polyclonal antibody (Cat# PAB29601) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
Immunofluorescent staining of methanol-fixed MCF7 cells using IGF1R (phospho Y1161) polyclonal antibody (Cat# PAB29601) at 1:100-1:200 dilution.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq