IGF1R (phospho Y1161) polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human IGF1R.
Immunogen
A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y1161 of human IGF1R.
Host
Rabbit
Theoretical MW (kDa)
200, 95
Reactivity
Human, Mouse, Rabbit
Specificity
IGF1R (phospho Y1161) polyclonal antibody detects endogenous level of IGF1R only when phosphorylated at tyrosine 1161.
Form
Liquid
Purification
Affinity Chromatography
Recommend Usage
Immunofluorescence (1:100-1:200)
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: 293 cells, Lane 2: Insulin treated 293 cells with IGF1R (phospho Y1161) polyclonal antibody (Cat# PAB29601) at 1:500-1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human breast cancer tissue by IGF1R (phospho Y1161) polyclonal antibody (Cat# PAB29601) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.Immunofluorescence
Immunofluorescent staining of methanol-fixed MCF7 cells using IGF1R (phospho Y1161) polyclonal antibody (Cat# PAB29601) at 1:100-1:200 dilution. -
Gene Info — IGF1R
Entrez GeneID
3480Protein Accession#
P08069Gene Name
IGF1R
Gene Alias
CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216
Gene Description
insulin-like growth factor 1 receptor
Omim ID
147370Gene Ontology
HyperlinkGene Summary
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq
Other Designations
soluble IGF1R variant 1|soluble IGF1R variant 2
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Interactome
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Pathway
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Disease
- Abortion
- Adenocarcinoma
- Adenoma
- Alzheimer disease
- Anemia
- Aneuploidy
- Atherosclerosis
- Bacteremia
- Barrett Esophagus
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Publication Reference
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Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells.
Chunye Liu, Changdong Lin, Daisong Wang, Jingqiang Wang, Yu Tao, Yue Li, Xinyi Chen, Lanyue Bai, Yingying Jia, Jianfeng Chen, Yi Arial Zeng.
Cell Reports 2022 Mar; 38(12):110548.
Application:WB, Human, Mouse, HEK 293T, Mammary stem cells.
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Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells.
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