Western blot analysis of Lane 1: Insulin (0.01 U/mL, 15 mins) treated NIH/3T3 cells, Lane 2: Synthesized peptide treated NIH/3T3 cells with WASF1 (phospho Y125) polyclonal antibody (Cat # PAB29590) at 1:500-1:3000 dilution.
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon carcinoma tissue with WASF1 (phospho Y125) polyclonal antibody (Cat # PAB29590) under 1:50-1:100 dilution (A) or treated with synthesized peptide (B).
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
OTTHUMP00000016990,Wiskott-Aldrich syndrome protein family member 1,homology of dictyostelium scar 1,verprolin homology domain-containing protein 1