Western blot analysis of Lane 1: EGF (200 ng/mL, 30 mins) treated Raw 264.7 cells, Lane 2: Synthesized peptide treated Raw 264.7 cells with STAT5B (phospho S731) polyclonal antibody (Cat # PAB29588) at 1:500-1:3000 dilution.
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast carcinoma tissue with STAT5B (phospho S731) polyclonal antibody (Cat # PAB29588) under 1:50-1:100 dilution (A) or treated with synthesized peptide (B).
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq