ADAM17 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human small intestine with ADAM17 polyclonal antibody (Cat # PAB29576) shows membranous and cytoplasmic positivity.
Immunofluorescence
Immunofluorescent staining of U-2 OS cells shows positivity in cytoplasm (green) with ADAM17 polyclonal antibody (Cat # PAB29576) under 1-4 ug/mL working concentration.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human ADAM17.
Immunogen
Recombinant protein corresponding to amino acids 105-237 of human ADAM17.
Sequence
SEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYR
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human small intestine with ADAM17 polyclonal antibody (Cat # PAB29576) shows membranous and cytoplasmic positivity.Immunofluorescence
Immunofluorescent staining of U-2 OS cells shows positivity in cytoplasm (green) with ADAM17 polyclonal antibody (Cat # PAB29576) under 1-4 ug/mL working concentration. -
Gene Info — ADAM17
Entrez GeneID
6868Protein Accession#
P78536Gene Name
ADAM17
Gene Alias
CD156b, MGC71942, TACE, cSVP
Gene Description
ADAM metallopeptidase domain 17
Omim ID
603639Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq
Other Designations
TNF-alpha converting enzyme|a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)|snake venom-like protease|tumor necrosis factor, alpha, converting enzyme
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Interactome
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Pathway
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Disease
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