Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with VCAM1 polyclonal antibody (Cat # PAB29573) shows moderate positivity in a subset of cells in germinal centers at 1:50 - 1:200 dilution.
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq