Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas with CD200 polyclonal antibody (Cat # PAB29572) shows cytoplasmic and nuclear positivity in exocrine glandular cells at 1:50 - 1:200 dilution.
The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq