THPO polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of THPO.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 307-337 at C-terminus of human THPO.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of THPO polyclonal antibody (Cat # PAB2956) in K-562 cell line lysates (35 ug/lane). THPO (arrow) was detected using the purified polyclonal antibody. -
Gene Info — THPO
Entrez GeneID
7066Protein Accession#
NP_000451;P40225Gene Name
THPO
Gene Alias
MGC163194, MGDF, MKCSF, ML, MPLLG, TPO
Gene Description
thrombopoietin
Gene Ontology
HyperlinkGene Summary
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. [provided by RefSeq
Other Designations
MPL ligand|c-mpl ligand|megakaryocyte colony-stimulating factor|megakaryocyte growth and development factor|megakaryocyte stimulating factor|myeloproliferative leukemia virus oncogene ligand|thrombopoietin nirs variant 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Congenital amegakaryocytic thrombocytopenia-3 novel c-MPL mutations and their phenotypic correlations.
Steinberg O, Gilad G, Dgany O, Krasnov T, Zoldan M, Laor R, Kapelushnik J, Gabriel H, Churi C, Stein J, Yaniv I, Tamary H.
Journal of Pediatric Hematology/Oncology 2007 Dec; 29(12):822.
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Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats.
Baker JE, Su J, Hsu A, Shi Y, Zhao M, Strande JL, Fu X, Xu H, Eis A, Komorowski R, Jensen ES, Tweddell JS, Rafiee P, Gross GJ.
Cardiovascular Research 2008 Jan; 77(1):44.
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A new role of thrombopoietin enhancing ex vivo expansion of endothelial precursor cells derived from AC133-positive cells.
Kanayasu-Toyoda T, Ishii-Watabe A, Suzuki T, Oshizawa T, Yamaguchi T.
The Journal of Biological Chemistry 2007 Sep; 282(46):33507.
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Congenital amegakaryocytic thrombocytopenia-3 novel c-MPL mutations and their phenotypic correlations.
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