PRPF4B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PRPF4B.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PRPF4B.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PRPF4B polyclonal antibody (Cat # PAB2951) in Jurkat cell lysate. PRPF4B (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the PRPF4B polyclonal antibody (Cat # PAB2951), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — PRPF4B
Entrez GeneID
8899Protein Accession#
NP_789770;Q13523Gene Name
PRPF4B
Gene Alias
KIAA0536, PR4H, PRP4, PRP4H, PRP4K, dJ1013A10.1
Gene Description
PRP4 pre-mRNA processing factor 4 homolog B (yeast)
Omim ID
602338Gene Ontology
HyperlinkGene Summary
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq
Other Designations
OTTHUMP00000039176|dJ1013A10.1 (PRP4 protein kinase homolog)|protein-serine/threonine kinase|serine/threonine-protein kinase PRP4 homolog|serine/threonine-protein kinase PRP4K
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Interactome
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Disease
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Publication Reference
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PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores.
Montembault E, Dutertre S, Prigent C, Giet R.
The Journal of Cell Biology 2007 Nov; 179(4):601.
Application:IF, WB-Tr, Human, HeLa cells.
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PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores.
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