Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testis with TCF3 polyclonal antibody (Cat# PAB29500) shows strong nuclear positivity in a subset of cells in seminiferus ducts.
Immunofluorescent staining of MCF-7 cells with TCF3 polyclonal antibody (Cat# PAB29500) under 1-4 ug/mL working concentration shows positivity in nucleus but excluded from the nucleoli. Antibody staining is shown in green.
The TCF3 gene, also called E2A, encodes 2 basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. E12 and E47 are involved in regulation of immunoglobulin gene expression (Bain et al., 1994 [PubMed 8001125]).[supplied by OMIM