Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with PRNP polyclonal antibody (Cat# PAB29494) shows moderate cytoplasmic positivity in Purkinje cells.
Immunofluorescent staining of U-2 OS cells with PRNP polyclonal antibody (Cat# PAB29494) under 1-4 ug/mL working concentration shows positivity in nuclear membrane and cytoplasm. Antibody staining is shown in green.
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
CD230 antigen,OTTHUMP00000030162,OTTHUMP00000030163,major prion protein,p27-30,prion protein PrP,prion-related protein