PRNP polyclonal antibody
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Specification
Product Description
PRNP polyclonal antibody raised against recombinant human PRNP.
Immunogen
Recombinant protein corresponding to amino acids of human PRNP.
Sequence
GSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with PRNP polyclonal antibody (Cat# PAB29494) shows moderate cytoplasmic positivity in Purkinje cells.Immunofluorescence
Immunofluorescent staining of U-2 OS cells with PRNP polyclonal antibody (Cat# PAB29494) under 1-4 ug/mL working concentration shows positivity in nuclear membrane and cytoplasm. Antibody staining is shown in green. -
Gene Info — PRNP
Entrez GeneID
5621Protein Accession#
P04156Gene Name
PRNP
Gene Alias
ASCR, CD230, CJD, GSS, MGC26679, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, prion
Gene Description
prion protein
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
CD230 antigen|OTTHUMP00000030162|OTTHUMP00000030163|major prion protein|p27-30|prion protein PrP|prion-related protein
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Interactome
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Pathway
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Disease
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