Western Blot (Cell lysate) analysis of Lane 1: Negative control (vector only transfected HEK293T lysate), Lane 2: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells) with SLC3A2 polyclonal antibody (Cat# PAB29491) at 1:100 - 1:250 dilution.
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with SLC3A2 polyclonal antibody (Cat# PAB29491) shows strong membranous positivity in tubular cells at 1:2500 - 1:5000 dilution.
Immunofluorescent staining of U-2 OS cells with SLC3A2 polyclonal antibody (Cat# PAB29491) under 1-4 ug/mL working concentration shows positivity in nucleus, plasma membrane and cytoplasm. Antibody staining is shown in green.
This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
4F2 cell-surface antigen heavy chain,4F2 heavy chain,CD98 heavy chain,antigen defined by monoclonal antibody 4F2, heavy chain,antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43,heavy chain,lymphocyte activation antigen 4F2 large subu