Western Blot analysis of Lane 1: RT-4 cell lysate, Lane 2: U-251 MG sp, Lane 3: Human plasma (IgG/HSA depleted), Lane 4: Human liver tissue, with FCAR polyclonal antibody (Cat# PAB29489) at 1:100 - 1:250 dilution.
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lymph node with FCAR polyclonal antibody (Cat# PAB29489) shows moderate cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction centra at 1:50 - 1:200 dilution.
Immunofluorescent staining of U-251 MG cells with FCAR polyclonal antibody (Cat# PAB29489) under 1-4 ug/mL working concentration shows positivity in vesicles. Antibody staining is shown in green.
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Fc alpha receptor,IgA Fc receptor,OTTHUMP00000068692,OTTHUMP00000068696,OTTHUMP00000068697,OTTHUMP00000068698