Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with PELI3 polyclonal antibody (Cat# PAB29481) shows strong cytoplasmic positivity in Purkinje cells while additional nuclear membranous staining in cells in molecular layer.
Immunofluorescent staining of A-431 cells with PELI3 polyclonal antibody (Cat# PAB29481) under 1-4 ug/mL working concentration shows positivity in vesicles and nucleus but excluded from the nucleoli. Antibody staining is shown in green.
Toll-like receptors (TLRs; see MIM 603030) and IL1R (IL1R1; MIM 147810) are part of the innate immune response aimed at mobilizing defense mechanisms in response in infection or injury. Pellino proteins, such as PELI3, are intermediate components in the signaling cascades initiated by TLRs and IL1R (Jensen and Whitehead, 2003 [PubMed 12874243]).[supplied by OMIM