Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with BRD4 polyclonal antibody (Cat# PAB29479) shows strong nuclear positivity in epidermal cells.
Immunofluorescent staining of PC-3 cells with BRD4 polyclonal antibody (Cat# PAB29479) under 1-4 ug/mL working concentration shows positivity in nucleus but excluded from the nucleoli. Antibody staining is shown in green.
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq
bromodomain-containing 4,bromodomain-containing protein 4,chromosome-associated protein