Immunohistochemical staining of human kidney with TRIP6 polyclonal antibody (Cat # PAB29450) shows strong cytoplasmic and membranous positivity in cells in tubules and cells in glomeruli at 1:50-1:200 dilution.
Immunofluorescent staining of human cell line U-2 OS with TRIP6 polyclonal antibody (Cat # PAB29450) at 1-4 ug/mL concentration shows positivity in plasma membrane, cytoplasm and focal adhesion sites.
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
OPA-interacting protein 1,thyroid receptor-interacting protein 6,zyxin related protein 1