Immunohistochemical staining of human pancreas with RNF10 polyclonal antibody (Cat # PAB29448) shows strong cytoplasmic positivity in exocrine glandular cells at 1:200-1:500 dilution.
Immunofluorescent staining of human cell line U-251 MG with RNF10 polyclonal antibody (Cat # PAB29448) at 1-4 ug/mL concentration shows positivity in mitochondria and nucleus but excluded from the nucleoli.
The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq