DBN1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant human DBN1.
Immunogen
Recombinant protein corresponding to human DBN1.
Sequence
PSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:500-1:1000)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney with DBN1 polyclonal antibody (Cat # PAB29439) shows strong membranous positivity in distal tubules.Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with DBN1 polyclonal antibody (Cat # PAB29439) at 1-4 ug/mL concentration shows positivity in plasma membrane and actin filaments. -
Gene Info — DBN1
Entrez GeneID
1627Gene Name
DBN1
Gene Alias
D0S117E, DKFZp434D064
Gene Description
drebrin 1
Omim ID
126660Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq
Other Designations
drebrin E|drebrin E2|drebrin-1
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