OPTN polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of Lane 1: Human cell line RT-4 Lane 2: Human cell line U-251MG sp with OPTN polyclonal antibody (Cat # PAB29401) at 1:100-1:250 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human oral mucosa with OPTN polyclonal antibody (Cat # PAB29401) shows strong cytoplasmic positivity in squamous epithelial cells at 1:200-1:500 dilution.
Immunofluorescence
Immunofluorescent staining of human cell line U-251 MG with OPTN polyclonal antibody (Cat # PAB29401) at 1-4 ug/mL concentration shows positivity in cytoplasm.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant human OPTN.
Immunogen
Recombinant protein corresponding to human OPTN.
Sequence
LGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKG
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
Immunofluorescence (1-4 ug/mL)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: Human cell line RT-4 Lane 2: Human cell line U-251MG sp with OPTN polyclonal antibody (Cat # PAB29401) at 1:100-1:250 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human oral mucosa with OPTN polyclonal antibody (Cat # PAB29401) shows strong cytoplasmic positivity in squamous epithelial cells at 1:200-1:500 dilution.Immunofluorescence
Immunofluorescent staining of human cell line U-251 MG with OPTN polyclonal antibody (Cat # PAB29401) at 1-4 ug/mL concentration shows positivity in cytoplasm. -
Gene Info — OPTN
Entrez GeneID
10133Gene Name
OPTN
Gene Alias
FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Gene Description
optineurin
Gene Ontology
HyperlinkGene Summary
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
Huntingtin interacting protein L|OTTHUMP00000019125|OTTHUMP00000019126|OTTHUMP00000019127|OTTHUMP00000019128|glaucoma 1, open angle, E (adult-onset)|nemo-related protein|transcrption factor IIIA-interacting protein|tumor necrosis factor alpha-inducible ce
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Interactome
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Disease
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