Western blot analysis of Lane 1: Human cell line RT-4; Lane 2: Human cell line U-251 MG sp; Lane 3: Human liver tissue; Lane 4: Human tonsil tissue with PDIA3 polyclonal antibody (Cat# PAB29335) at 1:100-1:250 dilution.
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq